March 20, 2020, Creative Proteomics has released choline and choline metabolites analysis service to assist researchers in their biotechnological projects. As leading supplier in proteomics, metabolomics, glycomics, and bioinformatics analysis services, Creative Proteomics has served researchers in pharmaceutical, biotechnology, agriculture and nutrition industries more than ten years. It has gained a good fame among clients from the whole world. With advanced biotechnological platform, Creative Proteomics is mainly focusing on the offering high-quality products and professional services to researchers both at home and abroad covering more than 50 countries and districts.
According to authoritative studies, choline protects the brain from Alzheimer's disease through two channels. For one, choline helps reduce homocysteine levels. The latter is a powerful neurotoxin that can cause neurodegeneration and the formation of amyloid plaques, double the prevalence of Alzheimer's disease. Choline acts as a chemical converter, converting harmful homocysteine into beneficial methionine. Second, choline can reduce microglial activation. Although the latter can clear debris from the brain, the activated microglia can easily get out of control, cause inflammation in the brain, and eventually cause neurons to die. Researchers say the discovery may open up new possibilities for treating a range of intergenerational diseases.
Studies show the significant role of choline in the clinical researches.
Additionally, choline can also promote brain development and improve memory, ensure information transmission, regulate cell apoptosis, constitute an important component of biofilms, promote fat metabolism, promote transmethylation in the body, and lower serum cholesterol.
“Choline is a positively charged tetravalent base, a constituent of all biofilms and a precursor of acetylcholine in cholinergic neurons. The concentration of choline in the cytoplasm is 8-25 micromoles / liter, and the concentration in the brain is 25-50 nanomoles / liter. Choline is obtained from the body through foods such as liver and eggs, or from endogenous synthetic PC. Except that the body obtains choline as part of the macromolecule PC, the body cannot produce choline through other routes. However, all cells apparently synthesize PC through PE methylation, and all cells are able to release choline from food and endogenous PC under the catalysis of phospholipase D or other phospholipases.” explained by Dr. Hamson, a senior scientist in R&D of Creative Proteomcis.
“With advanced technique and technology, scientists in Creative Proteomics have contributed a lot to ensure the feasibility and efficiency of our services. Customers can enjoy the most appropriate service.” Dr. Hamson added.
About Creative Proteomics
The advanced instrumentation, such as NMR, GC-MS, LC-MS, LC-MS/MS, HPLC-UV/FD, etc. in Creative Proteomics maintains the leading position in proteomics, bioinformatics. Since its establishment, Creative Proteomics is always holding the faith of providing high-quality products and professional services to customers from all over the world. What’s more, scientists from Creative Proteomics are also continuing to develop the practical products and services with the best performance in choline and choline metabolites.