What is metabolomics?
We know that metabolism is the general term for various chemical reactions in living organisms. It is one of the most important life activities of animals and plants. Individuals adapt to changes in internal and external environment through various metabolic adjustments, which is one of the basic characteristics of life activities. A "metabolome" is a collection of all metabolites in a biological sample. There are many kinds of metabolites (may be more than one million species) with various structures, and there are large differences in distribution and concentration in different tissues and body fluids. The main types include lipids, amino acids, organic acids, carbohydrates, nucleic acids, and so on.
Metabolomics is an independent discipline, systematically studying metabolomes that provides unique biochemical fingerprints of all cellular processes. It can be used to identify metabolic biomarkers elucidating underlying disease mechanisms or predicting environmental changes or external interventions reaction.
What is lipidomics?
Lipolipomics is an independent discipline that systematically studies lipid groups. As a method for large-scale qualitative and quantitative study of lipid compounds and understanding their functions and changes under different physiological and pathological conditions, it can accurately and comprehensively provide a full-fat information spectrum of biological samples under different physiological conditions.
As can be seen from the above definition, "lipolipomics" is actually a branch of "metabolomics." However, because lipid metabolism is the most major category of animal and plant metabolism (about 70% of metabolites in plasma is lipid), it is the hot spot of animal and plant metabolism research. Lipid metabolism is involved in energy transportation and intercellular information communication and network regulation in the process of growth and development. As a major component of cell membranes and lipid droplets, various structural lipids play an important role in a wide range of biological processes, such as signal transduction, transport, and biomacromolecule sorting with different biochemical properties. With the rapid development of lipidomics in recent years, scientists have gradually divided the lipid group research from mebabolism to “lipidomics”. Currently, when we refer to “metabolomics”, the lipid group analysis is no longer included.
Clinical application of lipidomics studies
Comprehensive analysis of lipids, i.e. lipidomics is a prerequisite for understanding the subtle dynamic changes and pathogenesis of lipids during cell changes. Lipid metabolism disorders and reproductive development defects are closely related to a variety of major diseases such as diabetes, cardiovascular disease, fatty liver, obesity, cancer, and Alzheimer's disease. The changes of lipid composition can directly reflect the physiological and pathological state of the organism.
Therefore, it is of great significance to analyze the changes of lipid spectrometry during the growth and development of tissues and organs and to analyze the mechanism of related metabolic regulation network.
With an integrated set of separation, characterization, identification and quantification system, featured with excellent robustness & reproducibility, high and ultra-sensitivity, Creative Proteomics provides reliable, rapid and cost-effective targeted lipidomics, untargeted lipidomics, Exosome Lipidomics and MALDI Imaging Lipidomics Service.
Advantages of Creative Proteomics Services
- The compounds we test are widely covered, ranging from small water-soluble molecules to large lipids.
- We can analyze any biological materials, including but not limited to biofluids and tissues from animals, cell cultures and humans.
- A comprehensive platform contains advanced instruments, including MS, GC-MS, LC-MS, NMR, and so on.
- A complete analysis report is offered, including method interpretation, data, and result files.